author alice

Posts Tagged ‘Antioxidant’

higher levels of selenium, vitamin E and carotenoids lycopene from tomatoes has been detected prostate cancer in a reduction of four white males, or those who say that a specific genetic change is particularly sensitive to stress oxidative die, U.S. researchers. Conversely, if carriers of this genetic variant have low levels of these vitamins and minerals, their risk of substantial increases in aggressive prostate cancer, as large as 10 times for higher concentrations of these nutrients they write in today’s issue of Cancer Research. “This large prospective study provides further evidence that oxidative stress may be one of the most important mechanisms for the development and progression of prostate cancer, and an adequate intake of antioxidants such as selenium , lycopene and vitamin E may help prevent prostate cancer, said Dr. Li Haoji, a researcher at Brigham and Women’s Hospital and Harvard Medical School. The new results are based on an analysis of 567 men with prostate cancer, 1982-1995, and 764 men without cancer study physicians diagnosed health is based. The initial aim of this study was to evaluate the effect of aspirin and beta-carotene to assess the health of men. Li team decided to test variants of the gene that codes for manganese superoxide to dismutatase (MnSOD), an important enzyme that works as an antioxidant in cells of the rights to defend themselves against the disease. The MnSOD gene is carried by parents to children in one of three forms: VV, VA or AA. “with men with the MnSOD VV or VA genotype comparison, people more sensitive to antioxidant status with the AA genotype seem, “said Li continued. “Men with the AA genotype are more susceptible to prostate cancer if their antioxidant properties are weak.” The results of the study revealed that a quarter of the men carried the MnSOD AA genotype of the study, half of which carried genotype VA, and the remaining quarter carried the VV genotype. The results showed that VA and VV men were at equal risk for prostate cancer at all levels of antioxidants in the blood. But MnSOD VV or VA carriers

in the lowest quartile of selenium levels, MnSOD AA compared with men had a risk of 89 per cent more likely to develop aggressive prostate cancer s if they had low blood levels of the mineral. On the other hand, MnSOD AA carriers had maintained with high selenium – men in the highest quartile – the risk 65 percent lower than the MnSOD VV or VA males, low selenium. “Selenium levels in the highest quartile of these men are not exceptionally high,” Li said. “Our offer is not very high nor very low.” ; Similar trends were observed for lycopene and vitamin E when tested independently, the contrast in relative risk was combined with men, blood pressure values for the three antioxidants had said, according to researchers. ” ; / P> “Among the men with the MnSOD AA genotype, we have a difference of 10 times the risk of aggressive prostate cancer, observed when comparing men with high versus low levels of antioxidants handsets, “said Li.” In contrast, among men with the VV or VA genotype, the risk of prostate cancer changed little by these antioxidant levels has been. “” Our study Like many other epidemiological studies, promotes the absorption of nutrients such as lycopene from tomatoes or supplements of vitamin E and selenium reduce the risk of prostate cancer, “Li said. ; Prostate cancer is a leading cause of cancer mortality in industrialized countries and affects more than 500,000 people per year worldwide. This number should increase with the aging of the population.

similar interactions between antioxidants and the variations in the MnSOD gene have been associated with the risk of breast cancer. For more information: Prostacet